NEW PUBLICATION

“Dynamic Point-to-Helical and Point-to-Axial Chirality Transmission and Induction of Optical Activity in Multichromophoric Systems: Basic Principles and Relevant Applications in Chirality Sensing”

T. Mądry, J. Gajewy, M. Kwit

Symmetry, 17(2), 293 (2025) https://doi.org/10.3390/sym17020293

Abstract:

The analysis of natural and artificial chiral compounds is vital wherever the nuances in the three-dimensional structure are decisive for the possibility of their further use, e.g., as pharmaceuticals or catalysts. The qualitative determination of the structure of a chiral entity requires either an anomalous scattering of X-ray radiation or chiroptical techniques, of which electronic circular dichroism (ECD) is one of the most useful. Chiroptical sensing that uses stereodynamic probes remains one of the remedies for the problem of the lack of a suitable chromophore in the molecules of the chiral compound. A covalent or non-covalent binding of an ECD-silent chiral molecule (the inducer) to the UV-active chromophoric system (chiroptical probe) led to obtaining complex ECD active at a given spectral region. The transfer of structural information from a permanently chiral inducer molecule to the structurally labile chromophoric system of the probe results in adjusting the latter’s structure to the chiral environment. This contribution focuses on some fundamental aspects of chirality sensing using conformationally labile probes. It discusses the mechanism of action of arbitrarily chosen stereodynamic chirality sensors, with particular emphasis on probes based on di- and triarylmethyl derivatives and biphenyl and its congeners.

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Medal of the Commission of National Education

dr habil. Jakub Grajewski among the laureates of the Medal of the Commission of National Education

On May 7, a ceremony was held in the Lubrański Hall of Collegium Minus, during which the Rector of Adam Mickiewicz University, Prof. Bogumiła Kaniewska, together with Agata Sobczyk, the Voivode of Greater Poland, presented Gold, Silver, and Bronze Medals for Long Service, as well as Medals of the National Education Commission, to AMU staff members.

Among those honored with the Medal of the National Education Commission was our colleague, Dr. habil. Jakub Grajewski.

Congratulations!

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NEW PUBLICATION

"Chirality and self-assembly of structures derived from optically active 1, 2-diaminocyclohexane and catecholamines"

HO Abdalla, M Warzańska, J Grajewski, R Mrówczyński

Nanotechnology Reviews 13 (1), 20240090 (2024) https://doi.org/10.1515/ntrev-2024-0090

Abstract:

Chiral biomimetic nanostructures were successfully synthesized through the oxidative polymerization of chiral and achiral catecholamines in the presence of optically active 1,2-diaminocyclohexane (DACH). Analysis of these nanostructures using circular dichroism confirmed their chiral nature, demonstrating the feasibility of inducing chirality in achiral polycatecholamine materials. Furthermore, the chiral nanostructures exhibited self-assembly behaviour, forming distinctive patterns or curly carpets-like structures on silicon surfaces. The arrangement and morphology of these structures were closely linked to the amount of DACH and its inherent chirality. Additionally, the self-assembly process was shown to be significantly influenced by the pH of the reaction and the choice of supporting materials. These findings are particularly relevant in the context of molecular self-assembly of nanoaggregates/particles generated during dopamine polymerization, suggesting a promising avenue for the development of novel chiral polycatechols-based materials.

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Stanford ranking laureate

Prof. Radosław Mrówczyński among the most cited scholars in the world!
The Stanford ranking includes the top 2% of the most cited scientists in 2021. Among them are individuals from Adam Mickiewicz University in Poznań – including Prof. Radosław Mrówczyński, PhD, from the Department of Organic Stereochemistry. Congratulations!

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