| Prof. Radosław Mrówczyński among the most cited scholars in the world! | ||
The Stanford ranking includes the top 2% of the most cited scientists in 2021. Among them are individuals from Adam Mickiewicz University in Poznań – including Prof. Radosław Mrówczyński, PhD, from the Department of Organic Stereochemistry. Congratulations! |
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"Chirality and self-assembly of structures derived from optically active 1, 2-diaminocyclohexane and catecholamines" HO Abdalla, M Warzańska, J Grajewski, R Mrówczyński Nanotechnology Reviews 13 (1), 20240090 (2024) https://doi.org/10.1515/ntrev-2024-0090 |
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Abstract: Chiral biomimetic nanostructures were successfully synthesized through the oxidative polymerization of chiral and achiral catecholamines in the presence of optically active 1,2-diaminocyclohexane (DACH). Analysis of these nanostructures using circular dichroism confirmed their chiral nature, demonstrating the feasibility of inducing chirality in achiral polycatecholamine materials. Furthermore, the chiral nanostructures exhibited self-assembly behaviour, forming distinctive patterns or curly carpets-like structures on silicon surfaces. The arrangement and morphology of these structures were closely linked to the amount of DACH and its inherent chirality. Additionally, the self-assembly process was shown to be significantly influenced by the pH of the reaction and the choice of supporting materials. These findings are particularly relevant in the context of molecular self-assembly of nanoaggregates/particles generated during dopamine polymerization, suggesting a promising avenue for the development of novel chiral polycatechols-based materials. |
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"Spectroscopic Studies of Lanthanide (III) Complexes with L-Malic Acid in Binary Systems" M Zabiszak, J Frymark, J Grajewski, R Jastrzab International Journal of Molecular Sciences 25 (17), 9210 (2024) https://doi.org/10.3390/ijms25179210
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Abstract: Binary systems of lanthanide ions (La, Nd, Gd, Ho, Tb, and Lu) with L-malic acid in molar ratios of 1:1 and 1:2 were studied. This study was carried out in aqueous solutions, and the composition of the formed complexes was confirmed using computer data analysis. The overall stability constants of the complexes and the equilibrium constants of the reaction were determined. The effect of ligand concentration on the composition of the internal coordination sphere of the central atom was observed. Changes in the coordination sphere of lanthanide ions were confirmed by spectroscopic measurements.
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"Thermodynamic Studies of Complexes in Cu(II)/Uridine-5′-Diphosphoglucuronic Acid System." K. Stachowiak, M. Zabiszak, J. Grajewski, A. Teubert, A. Bajek, R. Jastrząb Molecules 29, 3695, (2024) https://doi.org/10.3390/molecules29153695
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Abstract: A binary system of uridine-5′-diphosphoglucuronic acid with copper (II) ions was studied. Potentiometric studies in aqueous solutions using computer data analysis were carried out. The pH of dominance, the overall stability constants (logβ), and the equilibrium constants of the formation reaction (logKe) were determined for each complex compound formed in the studied system. Spectroscopic studies were carried out to determine the mode of coordination in the compounds studied. Cytotoxicity and metabolic activity tests of the compounds obtained showed an increase in the biological activity of the complexes tested against the free ligand. The current research may contribute to the knowledge of complex compounds of biomolecules found in the human body and may also contribute to the characterization of a group of complex compounds with potential anticancer properties.
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We are seeking candidates to pursue their passions within the project:
Molecular Geometry – Pre- and Post-Synthetically Modified, Solid-State Macrocycles with Significant Chiroptical Response, for Molecular Tectonics and Chirality Detection.
Details in the document below:
"Hydrogen and Chalcogen Bonds in Crystals of Chalcogenadiazolecarboxylic Acids – Competition or Cooperation?” J. Alfuth, A. Czapik, B. Zadykowicz, T. Olszewska CrystEngComm, 26, 2918-2927 (2024) https://doi.org/10.1039/D4CE00273C
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Abstract: This article presents crystal structures of chalcogenadiazolecarboxylic acids bearing both a hydrogen and a chalcogen bond donor. The selected molecules varied in the size of the aromatic unit, the chalcogen atom and/or the position of the carboxyl group in the core structure. The most common synthons in their lattice are R22(8) self-complementary acid dimers or four-membered [Ch⋯N]2 rings. Supramolecular synthons where chalcogenadiazole moieties interact with the carboxyl group were also identified. Both ESP calculations and experimental data showed that all the studied molecules adopted flat conformations, but only in the case of three crystal structures were flat sheets observed. To assess the contribution of hydrogen and chalcogen bonds to the stabilization of the crystal structure, crystal lattice energy calculations were performed.
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"Catalytic hydrosilylation of 1,3-diynes towards (E)-2-silylbut-1-en-3-ynes, (E,E)-2,3-disilylbuta-1,3-dienes and (E,E)-2-silyl1-3-silyl2buta-1,3-dienes" K. Stefanowska-Kątna, M. Szymkowiak, J. Nagórny, A. Czapik, J. Walkowiak, A. Franczyk J. Catal., 434, 115519 (2024) https://doi.org/10.1016/j.jcat.2024.11551
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Abstract: Hydrosilylation of 1,3-diynes produced (E)-2-silylbut-1-en-3-ynes, (E,E)-2,3-disilylbuta-1,3-dienes, and (E,E)-2-silyl1-3-silyl2buta-1,3-dienes, which due to their complex structure and susceptibility to modification could be used in the preparation of drugs or natural compounds. The application of Pt2(dvs)3, PtO2, or [Ir(cod)Cl]2 (at room temperature or 40 ℃) allowed us to obtain (E)-2-silylbut-1-en-3-ynes. Their further modification in the presence of Pt2(dvs)3 or Pt(en)Cl2 (at 140 °C) led to the exclusive formation of (E,E)-2,3-disilylbuta-1,3-dienes, and (E,E)-2-silyl1-3-silyl2buta-1,3-dienes (a new family of compounds not yet obtained by other methods). For the first time, Pt(en)Cl2 was found to be effective in the hydrosilylation of 1,3-diynes, while [Ir(cod)Cl]2 compared to the literature, surprisingly gave (E)-2-silylbut-1-en-3-ynes instead of (E)-4-silylbut-1-en-3-ynes. Moreover, the first crystal structure of (E,E)-2,3-disilylbuta-1,3-diene was reported.
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